일산화질소가 섬유주세포의 유착과 이동에 미치는 영향

• 영문명: Effect of Nitric Oxide on Adhesion and Migration of Trabecular Meshwork Cells
• 발행기관: 대한안과학회
• 저자명: 배진성 김재우,Jin Seong Bae, MD, Jae Woo Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number4, 639~644쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.04.30

영문 초록

Purpose: To investigate the effect of nitric oxide (NO) on the adhesion and migration of cultured human trabecular meshwork cells (HTMC). Methods: For adhesion assay, primarily cultured HTMC were attached to culture dishes for 1 hr, cells were rinsed, and the remaining adherent cells were assessed with MTT assay. Degree of cellular migration was assessed under normal and stressed conditions using microchemoattraction chambers. Effect of NO on the adhesion and migration was assessed with or without co-exposure of S-nitroso-N-acetylpenicillamine (SNAP). Results: NO did not affect the degree of adhesion or migration of HTMC (p ＞ 0.05). The degree of adhesion increased although the degree of migration decreased with 1% serum (p < 0.05). Degrees of migrations decreased after mechanical stress (p < 0.05). Conclusions: NO may not affect the adhesion or migration of HTMC.

키워드

Adhesion, Migration, Nitric oxide, Trabecular meshwork cells