가토 모델에서 소양막콘택트렌즈의 창상 치유 효과

• 영문명: The Wound Healing Effects of AmniSite-Lens in Rabbits
• 발행기관: 대한안과학회
• 저자명: 김태형 전연숙 김재찬,Tae Hyung Kim, MD, Yeoun Sook Chun, MD, PhD, Jae Chan Kim, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number2, 338~345쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.02.28

영문 초록

Purpose: The effects of AmniSite-Lens on wound healing were evaluated for a burn wound on a rabbit cornea. Methods: A chemical burn was inflicted on the cornea of rabbits using 0.1N NaOH and a superficial keratectomy with trephine was performed. The control group consisted of rabbits with a bandage contact lens (Focus Lens) after the operation. In the other group, the AmniSite-Le was applied on the rabbits’ cornea. The rabbits were evaluated for the following: 1) the time of epithelialization; 2) the grade of corneal opacity; and 3) the histological analysis by evaluation of inflammatory reaction and apoptotic keratocytes. Results: In the alkali-burn model, the time of epithelialization in the AmniSite-Lens group was not statistically significant compared with the bandage contact lens group. There was no difference of corneal opacity at postoperative week 1. The corneal opacity in the AmniSite-Lens group was clearer than the bandage contact lens group at postoperative weeks 4 and 8 and the difference of corneal opacity was statistically significant. In the keratectomy model, the time of epithelialization in the AmniSite-Lens group was not statistically significant compared with the bandage contact lens group. The corneal opacity in the AmniSite-Lens group was clearer than the bandage contact lens group at postoperative weeks 1 and 4 and the difference of corneal opacity was statistically significant. Conclusions: The AmniSite-Lens has both the wound healing effect of an amniotic membrane and the convenience of a bandage contact lens.

키워드

Amniotic membrane, Amniotic membrane contact lens, AmniSite-Lens, Chemical burn, Wound healing