패턴 스캐닝 레이저과 기존 방법을 이용한 광응고술 후 가토 유리체강의 염증성 사이토카인

• 영문명: Inflammatory Cytokines in the Vitreous of Rabbits after Photocoagulation Using Pattern Scanning and Conventional Laser
• 발행기관: 대한안과학회
• 저자명: 최영락 변익수 이승욱 신민규 이지은 엄부섭 ,Young Rock Choi, MD, PhD, Ik Soo Byon, MD,, Seung Uk Lee, MD, Min Kyu Shin, MD,Ji Eun Lee, MD, PhD,, Boo Sup Oum, MD, PhD,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number1, 149~154쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.01.15

영문 초록

Purpose: To compare concentration of cytokines in the vitreous of rabbit eyes after photocoagulation using a short-pulse pattern scanning laser (PASCAL) or a conventional laser. Methods: Laser photocoagulation was performed using PASCAL (duration 0.02 seconds) in the right eyes and a conventional laser (duration 0.1 seconds) in the left eyes of 13 pigmented rabbits. To obtain ophthalmoscopically similar mild burns, power was adjusted during the photocoagulation. The rabbits were sacrificed at 1, 3 or 7 days after photocoagulation to investigate histological changes. Levels of interleukins (IL)-1β, IL-6, IL-8 and tumor necrosis factor (TNF)-α in the vitreous humors of ten rabbits were measured using enzyme-linked immunosorbent assay before treatment and at 1, 3 and 7 days after photocoagulation. Results: Histological changes were comparable between the two groups. IL-1β and TNF-α were not detectable. IL-6 did not change significantly. IL-8 increased at day 3 and day 7, but no significant difference was observed between the two groups (p＞0.05). Conclusions: When ophthalmoscopically similar mild burn intensity was achieved, conventional and PASCAL treatments of rabbit eyes caused no difference in intravitreal concentration of inflammatory cytokines.

키워드

Cytokine, Interleukin, Patterned scanning laser, Photocoagulation