세균각막염 원인균주의 항생제 감수성과 초기 항생제 선택의 적절성

• 영문명: Antibiotics Susceptibility in Bacterial Keratitis and Proper Initial Treatment
• 발행기관: 대한안과학회
• 저자명: 윤제환 정지웅 문현승 문호석 신경환 김균형,Je Hwan Yoon, MD, Jee Woong Jung, MD, Hyun Seung Moon, MD, Ho Seok Moon, MD,Kyung Hwan Shyn, MD, PhD, Kyun Hyung Kim, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number1, 38~45쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.01.15

영문 초록

Purpose: The present study aims to determine the common pathogens involved in the etiology of bacterial keratitis and to analyze not only the antibiotic susceptibility of bacterial isolates from patients with bacterial keratitis but also the propriety of initial treatment. Methods: A retrospective study of 161 eyes in 161 patients with bacterial keratitis, who were diagnosed by cultures from 2000 to 2011, was performed. Causative bacteria and antibiotic susceptibility were evaluated in consecutive 6-year periods. Results: The most common bacteria was the pseudomonas species in the 2 time periods tested and cefazolin with tobramycin was the most commonly used antibiotic (125 cases, 77.6%) for initial treatment of bacterial keratitis. In vitro testing showed gram-negative susceptibility to tobramycin and ciprofloxacin was over 70%, gram-positive susceptibility to cephalothin and vancomycin was 100% and there was no significant difference between the 2 time periods tested. Eight cases had resistance to the initial treatment, but only 1 case showed treatment failure. Conclusions: Antibiotics used for initial treatment of bacterial keratitis were able to obtain a proper effect but several cases showed bacterial resistance to antibiotics. Thus, continued testing is essential to monitor for antibiotic resistance.

키워드

Antibiotics, Antibiotic susceptibility, Bacterial keratitis, Resistance