고용량 스테로이드 치료에 추가 트리암시놀론 구후주사가 구후시신경염의 시력회복에 미치는 영향

• 영문명: Additional Retrobulbar Triamcinolone Acetonide Injection for Retrobulbar Optic Neuritis Patients
• 발행기관: 대한안과학회
• 저자명: 박준호 신재필 전보영,Joon Ho Park, MD, Jae Pil Shin, MD, PhD, Bo Young Chun, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number1, 117~122쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.01.15

영문 초록

Purpose: To evaluate the effect of additional retrobulbar triamcinolone acetonide (TA) injection on early recovery of visual acuity in retrobulbar optic neuritis patients. Methods: A prospective, randomized clinical study including 30 patients with retrobulbar optic neuritis was conducted between March 2003 and June 2007. Patients were divided into 2 groups: Group 1 (n = 9) with retrobulbar triamcinolone (TA, 40 mg/1 ml) injection on the first day of ONTT protocol, and group 2 (n = 21) with conventional ONTT protocol. The following parameters were measured and analyzed: patient’s sex, age, pupillary reactions, color vision, visual field, and best-corrected visual acuity before treatment, and after 1 day, 1 week, 2 weeks, 1 month, and 3 months of follow-up. Results: Mean visual acuity before treatment was 1.00 ± 0.89 log MAR units in group 1 and 0.98 ± 0.75 log MAR units in group 2. One day after injection, visual acuity was better in group 1 (0.50 ± 0.42 log MAR units) than in group 2 (0.73 ± 0.61 log MAR units), however, there was no statistically significant difference between the 2 groups (p = 0.07). There was no significant difference in visual acuity, recovery of RAPD, color vision, or visual field at 3 months of follow-up. No serious side effect related to retrobulbar TA injection was observed. Conclusions: Additional retrobulbar TA injection may help optic neuritis patients who have a need for prompt visual recovery. However, further studies are required to ascertain whether this procedure can help early recovery of visual acuity in retrobulbar optic neuritis patients.

키워드

Best corrected visual acuity, Retrobulbar optic neuritis, Retrobulbar triamcinolone acetonide injection