쥐의 외안근 부분 절개술 후 데코린과 종양성장인자-베타의 발현

• 영문명: Decorin and TGF-β Expression after Partial Myotomy of the Extraocular Muscle in Rat
• 발행기관: 대한안과학회
• 저자명: 임영진 김규남 이나은 김성재 유지명,Young Jin Lim, MD, Gyu Nam Kim, MD, Na Eun Lee, MD, Sung Jae Kim, MD, Ji Myong Yoo, MD, PhD,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume54,number1, 143~148쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2013.01.15

영문 초록

Purpose: To report the expression of decorin and TGF-β in partial myotomy of the extraocular muscle in rats. Methods: Partial myotomy of the superior rectus muscle was performed on the right eye of 10 Sprague-Dawley rats followed by exposure of the left superior rectus muscle and a simple suture of the conjunctiva. The bilateral superior rectus muscle was obtained from all rats at 2 weeks postoperatively. The tissues were observed under light microscopy with hematoxylin- eosin, Masson’s trichrome staining and immunohistochemistry. Results: Histological examinations of the surgical area at 2 weeks after postoperatively showed irregularly concentrated fibrosis on light microscopy with hematoxylin-eosin and Masson’s trichrome staining of the experimental eyes. Immnohistochemistry showed that expression of decorin was in the same location as TGF-β in the experimental group. Conclusions: The expression of decorin was found in the healing process after partial myotomy of the extraocular muscle in rats. Immunohistochemistry showed that expression of decorin was in the same location as with TGF-β.

키워드

Decorin, Extraocular muscle, Fibrosis, Tumor growth factor