녹내장 환자에서 망막전위도의 ON-OFF 반응 소견

• 영문명: ON and OFF Responses of the Electroretinogram in Patients with Glaucoma
• 발행기관: 대한안과학회
• 저자명: 박가희 장지호 박태관 온영훈,Ka Hee Park, MD, Ji Ho Chang, MD, Tae Kwan Park, MD, PhD, Young Hoon Ohn, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume53,number8, 1104~1111쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.08.15

영문 초록

Purpose: To investigate whether there is a difference in ON- and OFF-responses of the photopic electroretinogram (ERG) in glaucomatous eyes. Methods: Photopic ERG and optical coherence tomography were performed in 15 normal, 13 glaucoma suspect, and 22 glaucoma subjects. Amplitudes and implicit times for a, b, d, i, photopic negative response (PhNR), and retinal nerve fiber layer thickness were compared among the three groups. Results: The PhNROFF amplitude (μV) was 19.05 ± 11.41 in the glaucoma group, 14.24 ± 10.37 in the glaucoma suspect group, and 2.69 ± 12.16 in the normal group, demonstrating a significant difference among the three groups (p < 0.01). The PhNRON amplitude (μV) was 20.15 ± 13.99 in the glaucoma group, 31.49 ± 17.09 in the glaucoma suspect group, and 37.59 ± 9.53 in the normal group, a significant difference (p < 0.01). However, there was no significant difference between the three groups. The ON-OFF response PhNR amplitude was correlated with retinal nerve fiber thickness (r = 0.481, r = -0.480, respectively), and areas under the receiver operating characteristic curve were 0.782, and 0.718, respectively. Conclusions: There is a potential role for the ON-OFF response PhNR in early detection of glaucomatous damage. J Korean Ophthalmol Soc 2012;53(8):1104-1111

키워드

Electroretinogram, Glaucoma, ON-OFF response, Photopic negative response