보리코나졸 점안이 배양 양성 진균각막염 치료에 미치는 임상 효과의 분석

• 영문명: Clinical Efficacy of Topical Voriconazole as Treatment in Culture-Positive Fungal Keratitis
• 발행기관: 대한안과학회
• 저자명: 윤창호 김미금 위원량,Chang Ho Yoon, MD,, Mee Kum Kim, MD, PhD,, Wong Ryang Wee, MD, PhD,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume53,number8, 1068~1075쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.08.15

영문 초록

Purpose: To evaluate the efficacy of topical voriconazole in treatment of culture-positive fungal keratitis. Methods: Twenty-two cases of culture-positive fungal keratitis treated with topical anti-fungal drugs from October 2004 to December 2010 were evaluated and medical records were reviewed. Patients were divided into 3 groups according to the method of topical antifungal treatment; the first group (V, n = 6) received voriconazole monotherapy, the second group (V+, n = 10) received topical voriconazole and amphotericin B combined therapy, and the third group (A, n = 6) received amphotericin B monotherapy. Results: The treatment success rate between the 3 groups was not significantly different. The epithelial defect healing time of group V was shorter than group V+. Treatment failure risk factors included Fusarium spp. infection and the presence of hypopyon. Eight eyes received topical voriconazole maintenance therapy for 66 days and there were no corneal erosions or epithelial defects. Conclusions: In fungal keratitis, topical voriconazole is as effective as other standard treatments and provides a faster healing time in the corneal epithelium than other standard treatments. However, voriconazole should be used with caution and therapeutic surgery should be considered in Fusarium spp. infections. J Korean Ophthalmol Soc 2012;53(8):1068-1075

키워드

Amphotericin B, Fungal keratitis, Voriconazole