백색토끼에서 수술 현미경에 노출 후 망막의 변화

• 영문명: Retinal Changes in White Rabbits after Exposure to the Light of an Operating Microscope
• 발행기관: 대한안과학회
• 저자명: 이정규 김호영 조호균,Jeong Kyu Lee, MD, PhD, Ho Young Kim, MD, Ho Kyun Cho, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number5, 603~609쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.05.15

영문 초록

Purpose: This study was performed to investigate the potential damage to white rabbit retinas caused by an operating microscope light. Methods: A total of 18 white rabbits were exposed to the light of an operating microscope for 60 minutes. Fundus examination, fluorescein angiography (FAG), and electroretinogram (ERG) were performed before exposure and 1 hr, 1 day, 7 days and 14 days afterward to allow for serial comparisons. Light and electron microscopic examinations were performed to evaluate the changes in the rabbit retinas over time. Results: Signs of retinal damage upon fundus examination and FAG were not found before or after exposure to the light of an operating microscopy. ERG, however, showed significant reduction in the dark-adapted rod response 1 hour after light exposure, and significant decline in the amplitude of the maximal combined response a- and b-wave 1 day after light exposure in the rabbit retinas. ERG findings returned to the pre-exposure level after 2 weeks. Ultrastructural injury to the photoreceptor outer segments and the retinal pigmented epithelium, observed using transmission electron microscopy, recovered to the pre-exposure state after 2 weeks. Conclusions: The risk of retinal damage should be considered as an early result of exposure to the light of an operating microscope, even in normal retinal findings. J Korean Ophthalmol Soc 2011;52(5):603-609

키워드

Electroretinogram, Operating microscope, Photoreceptor, Phototoxicity, Retinal pigment epithelium