브리모니딘 분무와 관류에 따른 눈물배출계의 형태학적 변화

• 영문명: Changes in the Lacrimal Excretory System Depending on the Administration Mode of Brimonidine Tartrate: Spray vs. Irrigation
• 발행기관: 대한안과학회
• 저자명: 양현승 오동은,Hyun Seung Yang, MD, Dong Eun Oh, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number5, 511~518쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.05.15

영문 초록

Purpose: To investigate the effects of 0.15% brimonidine tartrate ophthalmic solution spray on the luminal changes in the nasolacrimal excretory system. Methods: A prospective study was performed on 52 eyes in 26 patients complaining of epiphora in both eyes. The randomly- assigned 26 test eyes (cases) received spray of the solution through the nasal cavity, and the other 26 eyes (controls) were irrigated with the same drug through the inferior calnaliculus. Dacryocystography was then performed to observe the luminal changes jn the nasolacrimal excretory system, patient symptoms and physiologic drainage functions. Results: The changes in lumen width of the nasolacrimal duct (NLD) were noted, and the changes in lumen width of the lacrimal sac were not significant in either mode. The upper and middle parts of the NLD were widened more in the irrigation group, and the lower part of the NLD was widened more in the spray group. Though there was no significant difference in the physiologic drainage functions, the patients in both groups reported reduced symptoms. Conclusions: Brimonidine tartrate spray altered the width of the NLD and improved the subjective symptoms of patients. Therefore, the spray can be applied in functional NLD obstruction patients before the surgical procedure. J Korean Ophthalmol Soc 2011;52(5):511-518

키워드

onidine tartrate, Dacryocystography, Epiphora, Nasolacrimal duct