마이토마이신 C가 흰 쥐의 속눈썹 재성장에 미치는 영향

• 영문명: Effects of Mitomycin C on Eyelash-Regrowth in Epilated Rats
• 발행기관: 대한안과학회
• 저자명: 김체론 유웅선 김경현 서성욱,Che Ron Kim, MD, Woong Sun Yoo, MD, Kyeong Hyun Kim, MD, Seong Wook Seo, MD, PhD,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number12, 1501~1506쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.12.15

영문 초록

Purpose: The aim of the present study was to determine the effects of mitomycin C (MMC) on eyelash regrowth in rats. Methods: Ten rats were subjected to bilateral eyelid epilation. One drop of 0.04% MMC solution and one drop of normal saline was then administered to the right and left eyelid, respectively. Three months post-epliation, the number of regrown eyelashes was counted, and a section of tissue from each eyelid was examined under light- and electron microscopies. Results: The number of regrown long eyelashes was 1.0 ± 0.81 on the right, and 12.5 ± 1.08 on the left. The rate of regrowth was 7.35 ± 5.55% on the right and 98.45 ± 3.27% on the left. Histological examination revealed no significant differences between the right and left eyelids, except for the absence of any hair shafts in the follicles on the right. However, electron microscopy revealed mitochondrial damage in the follicles of the right eyelid. These changes were not observed in tissue from the left eyelid. Conclusions: The application of 0.04% MMC inhibited the regrowth of normal eyelashes in rats following simple epilation. These results suggest that MMC may be a novel therapy for replacing invasive surgery in trichiasis with no malpositioning. J Korean Ophthalmol Soc 2011;52(12):1501-1506

키워드

Eyelash, Mitomycin C, Trichiasis