라섹 수술 후 통증에 대한 비스테로이드성 항염증 점안액의 선행 진통 효과

• 영문명: Preemptive Analgesic Effect of Topical NSAIDS in Postoperative Pain Relief after LASEK
• 발행기관: 대한안과학회
• 저자명: 김세경 홍진표 남상민 서경률,Se Kyung Kim, MD, Jin Pyo Hong, MD, Sang Min Nam, MD, Kyoung Yul Seo, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number12, 1414~1418쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.12.15

영문 초록

Purpose: To assess the preemptive analgesic effect of topical NSAIDs (0.5% ketorolac tromethamine, Acular) as postoperative pain relief in patients undergoing LASEK. Methods: A prospective, randomized, placebo-controlled, paired eye study was performed. Patients undergoing LASEK were randomized to receive 0.5% ketorolac in one eye and 0.3% ofloxacin (placebo) in the contralateral eye at 30 minutes, 20 minutes, or ten minutes prior to LASEK. Pain was assessed using a visual analog scale of 0 to 10 in each eye 6, 12, 24, 36, 48 and 72 hours after surgery. Patients were also asked to assess the levels of glare, tearing and irritation using a visual analog scale from 0 to 10. Results: A total of 62 eyes from 31 patients were enrolled in the present study. The mean postoperative pain score in the NSAID group was significantly lower than that in the placebo group at postoperative hours 6 (2.35 versus 4.97), 12 (2.52 versus 5.16), and 24 (3.84 versus 4.94) (p < 0.05). The mean postoperative pain score after 36 and 48hours was also lower in the NSAID group than in the placebo group, but the differences were not statistically significant (p > 0.05). Patients reported significantly less tearing and irritation in the NSAID-administered eye compared to those in the placebo eye after LASEK (p < 0.05). Conclusions: Preemptive administration of topical NSAIDs before LASEK was effective in reducing acute postoperative pain. Preemptive analgesia with topical NSAIDs may be a valuable treatment option for controlling postoperative pain following ocular surgery. J Korean Ophthalmol Soc 2011;52(12):1414-1418

키워드

LASEK, Nonsteroidal anti-inflammatory drug, Pain, Preemptive analgesia