한국인 망막모세포종의 발생률(1991~1993)과 생존율(1991-2003) 보고

• 영문명: Incidence (1991~1993) and Survival Rates (1991-2003) of Retinoblastoma in Korea
• 발행기관: 대한안과학회
• 저자명: 김정훈 유영석,Jeong Hun Kim, MD, Young Suk Yu, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number4, 542~551쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.04.15

영문 초록

Purpose: To determine the incidence (1991~1993) and survival rates (1991~2003) of retinoblastoma in Korea. Methods: Data of all Korean patients diagnosed with retinoblastoma from 1991-1993 were retrospectively collected by the hospital- based national registry based on notifications from physicians who are able to diagnose retinoblastoma. The incidence rate (1991~1993) was calculated per 100,000 childbirths (dividing the number of retinoblastoma patients by the total number of childbirths). The survival rate (1991~2003) was calculated using the Kaplan–Meier method, and the differences were evaluated with the logrank and Wilcoxon tests and Cox’s proportional hazards model.In addition, the clinical findings and prognostic factors associated with survival rate were analyzed. Results: There were a total of 108 distinct patients diagnosed with retinoblastoma in the registry. The incidence of retinoblastoma in Koreawas 4.99 per 100,000 childbirths, and the survival rate for 13 years (1991-2003) was 77.8%. The survival rate was significantly lower in the population of bilateral retinoblastomapatients, as compared to unilateral retinoblastoma patients. Optic nerve invasion was found to be an independent variable for the reduction of survival rate, although its effects were not significant. Conclusions: In the present study, the incidence and survival rates of retinoblastoma in Koreawere presented for the first time. The incidence rate was similar to rates reported from other countries. On the other hand, the survival rate was lower than those in European and the United States. In particularly, the survival rate was significantly lower in patients with bilateral retinoblastoma. J Korean Ophthalmol Soc 2010;51(4):542-551

키워드

Incidence rate, Retinoblastoma, Survival rate