전층각막이식술 후 발생한 감염성 각막염의 임상양상 및 위험인자

• 영문명: Clinical Manifestation and Predisposing Factors of Infectious Keratitis Following Penetrating Keratoplasty in Korean Patients
• 발행기관: 대한안과학회
• 저자명: 김미진 오주연 김미금 한상범 이진학 위원량,Mijin Kim, MD, Joo Youn Oh, MD,, Mee Kum Kim, MD,, Sang Beom Han, MD,, Jin Hak Lee, MD,, Won Ryang Wee, MD,
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number4, 504~509쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.04.15

영문 초록

Purpose: To report the clinical manifestation, predisposing factors, microbiological profiles and treatment outcome of infectious keratitis following penetrating keratoplasty (PK). Methods: Medical records of the post-PK patients later diagnosed with culture-positive keratitis, between January 2003 and June 2008 at our hospital were retrospectively reviewed. Results: Among 228 eyes of 226 patients who previously had PK, 18 eyes (7.89%) of 16 patients developed microbial keratitis. Fifteen patients had a bacterial infection, of which a Streprococcus species was the most common causative microorganism (6 eyes, 33.3%). Three eyes had fungal infection; one case was co-infected with bacteria. Six eyes (33.3%) presented with a suture-related problem, and sixteen eyes (88.9%) had been using topical glaucoma medications. The suture-related problem and use of glaucoma medication were significantly associated with the development of infectious keratitis (p=0.040 and 0.013, respectively). Remission was achieved in all cases within the mean duration of 2.47 months after treatment initiation. However, visual improvement was not achieved in 11 eyes (68.7%) due to graft opacity. Conclusions: Early identification of predisposing factors and appropriate management at an early stage may prevent the occurrence of graft infection and improve graft survival. J Korean Ophthalmol Soc 2010;51(4):504-509

키워드

Cornea, Infections, Penetrating keratoplasty