거대세포바이러스 망막염의 임상양상 및 예후에 대한 고찰

• 영문명: Cinical Manifestations and Prognosis of Cytomegalovirus Retinitis
• 발행기관: 대한안과학회
• 저자명: 권영교 채주병 함돈일,Young Kyo Kwun, MD, Ju Byung Chae, MD, Don Il Ham, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number2, 203~209쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.02.15

영문 초록

Purpose: Cytomegalovirus (CMV) retinitis is common in patients with immunodeficient conditions caused by acquired immunodeficiency syndrome (AIDS), cytotoxic chemotherapy and immunosuppresive treatment. The purpose of this study was to assess the clinical manifestations and prognosis of CMV retinitis cases. Methords: Thirty-one eyes of 21 patients who were diagnosed with CMV retinitis were retrospectively reviewed. The clinical manifestations and prognosis of all patients were analyzed. Results: The average age of patients was 24.4±19.8 years. Eight patients were female and 13 patients were male. The predisposing conditions of patients were leukemia (nine patients), immunosuppressed conditions due to organ transplantation (three patients), AIDS (two patients) and other (seven patients). Eleven patients exhibited bilateral disease. The mean follow-up period was 31.3 months, and there were no differences between mean initial visual acuity (0.70±0.31) and mean visual acuity (0.77±0.20) at final visit. The major causes of visual loss were retinitis and atrophic changes involving the macula. Although retinitis was successfully treated with anti-viral agents in all cases, cataract (10 eyes, 31.3%), cystoid macular edema (four eyes, 12.5%), retinal detachment (two eyes, 6.3%), epiretinal membrane (two eyes, 6.3%) and immune recovery uveitis (two eyes, 6.3%) developed after the initial treatment. Conclusions: Although the visual prognosis of CMV retinitis was relatively good after administration of appropriate antiviral therapy, clinicians should remain alert for the development of late complications, including retinal detachment, cystoid macular edema and immune recovery uveitis. J Korean Ophthalmol Soc 2010;51(2):203-209

키워드

Cinical manifestations, Cytomegalovirus retinitis, Prognosis