폐경기 여성의 호르몬 대치요법이 안구건조증상에 미치는 영향: 전향적 연구보고

• 영문명: Effect of Hormone Replacement Therapy on Dry Eye Syndrome in Postmenopausal Women: A Prospective Study
• 발행기관: 대한안과학회
• 저자명: 문정현 정지웅 신경환 백혜정,Jung Hyun Moon, MD, Jee Woong Jung, MD, Kyung Hwan Shin, MD, PhD, Hye Jung Paik, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number2, 175~179쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.02.15

영문 초록

Purpose: To evaluate the effects of conjugated hormone replacement therapy (HRT) on dry eye syndrome in postmenopausal women. Methods: Thirty-six healthy postmenopausal women (72 eyes) were included in this three- month prospective study. Schirmer test, tear film break-up time (BUT), fluorescein staining score and symptom score were performed on all patients at the time of enrollment, one month and three months after initiation of HRT. All patients received HRT consisting of conjugated estrogen and progesterone taken orally in a continuous combined regimen. Results: Symptom score significantly decreased from 2.10±0.79 before HRT to 1.32±0.84 after one month and to 0.88±0.67 after three months (p＜0.001). In addition, tear film BUT measurements significantly increased from 6.04±2.54 seconds to 7.99±2.43 seconds after one month and to 8.93±2.20 after three months (p＜0.001). The fluorescein staining score was 0.94±0.71 before HRT and decreased to 0.42±0.60 after one month and to 0.22±0.42 after three months (p＜0.001). Conclusions: Hormone replacement therapy consisting of conjugated estrogen and progesterone significantly improved the symptoms and signs of dry eye syndrome in postmenopausal women. J Korean Ophthalmol Soc 2010;51(2):175-179

키워드

Dry eye syndrome, Hormone replacement therapy, Postmenopausal woman