도졸라마이드-티몰롤과 라타노프로스트가 가토 방수의 산화환원계에 미치는 영향

• 영문명: The Effect of Dorzolamide-Timolol and Latanoprost on Redox Cycle in Aqueous Humor of Rabbit
• 발행기관: 대한안과학회
• 저자명: 박상우 이승현 문귀형,Sang Woo Park, MD, Seung Hyun Lee, MD, Gui Hyeong Mun, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number3, 424~428쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.03.15

영문 초록

Purpose: To evaluate the effect of dorzolamide-timolol and latanoprost on redox cycle of superoxide dismutase (SOD) and ascorbic acid in the aqueous humor of the rabbit. Methods: Group 1 (20 eyes of 10 rabbits) was instilled with dorzolamide-timolol in the right eye and Group 2 (20 eyes of 10 rabbits) was instilled with latanoprost in the same manner. Four weeks after instillation, SOD activity and ascorbic acid concentration were analyzed. Results: In Group 1, SOD activity and ascorbic acid concentration of the right eye and left eye were 15.7% and 19.3% (p=0.27), 2.7 pM and 2.6 pM (p=0.47), respectively. In Group 2, SOD activity and ascorbic acid concentration of the right and left eye were 22.3% and 27.6% (p=0.14), 2.3 pM and 2.1 pM (p=0.89), respectively. Conclusions: There was no significant difference of SOD activity and ascorbic acid concentration between both eyes in Group 1 and 2.

키워드

Ascorbic acid, Dorzolamide-timolol, Latanoprost, Superoxide dismutase