만성중심장액맥락망막병증에서의 광역학치료의 효과: 다기관 공동연구

• 영문명: Photodynamic Therapy for Chronic Central Serous Chorioretinopathy: Multicenter Study of 65 Cases
• 발행기관: 대한안과학회
• 저자명: 오재령 권오웅 김민호 김종인 김하경 김형찬 남동흔 박규형 손준홍 엄부섭 유승영 윤영희 윤일한 윤희성 이재흥 이정희 이지은 장우혁 조성원 진희승 허걸 곽형우
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number3, 390~398쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.03.15

영문 초록

Purpose: To determine the effect of photodynamic therapy (PDT) on patients with chronic central serous chorioretinopahty (CSC). Methods: This was a retrospective multicenter study. We collected demographic and ophthalmic data for patients with chronic CSC who were treated with PDT from 16 institutions in Korea. The best corrected visual acuity (BCVA), ophthalmoscopic finding and optical coherence tomography at baseline and follow-up visits were compared longitudinally. Results: Sixty-five eyes of 65 patients were recruited. Males (51 patients, 78.5%) outnumbered females (14 patients, 21.5%). The mean age was 46.4±10.0 years of age (28~69). By 1 month, mean BCVA improved from 0.47 to 0.37 (logarithm of the minimum angle of resolution) (P <0.01). This BCVA increased throughout 6 months. Subretinal fluid resolved partially or completely in 89.1% of the patients. Central macular thickness (CMT) decreased from 303.4 to 168.7 μm. The amount of change in CMT after PDT was correlated to the female sex and prePDT CMT. At 3 months after PDT, the amount of change in BCVA was significantly related to that of change of CMT (p <0.05). Adverse events were reported in 4 cases, however, most were mild. Conclusions: PDT was effective and safe for treating chronic CSC.

키워드

BCVA, Chronic CSC, CMT, PDT