건성안 환자의 진단에서 결막솔질검사의 유용성에 관한 연구

• 영문명: Clinical Usefulness of Conjunctival Brush Cytology in the Diagnosis of Dry Eye Syndrome
• 발행기관: 대한안과학회
• 저자명: 문형진 박창수 윤경철,Hyung-Jin Moon, MD, Chang-Su Park, MD, Kyung-Chul Yoon, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number3, 340~346쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.03.15

영문 초록

Purpose: To investigate the clinical usefulness of conjunctival brush cytology (CBC) in the diagnosis of dry eye syndrome. Methods: Conjunctival impression cytology (CIC) was performed on the right eye and CBC was performed on the left eye in 24 patients with dry eye syndrome (9 patients with Sjӧgren’s syndrome (SS) and 15 patients with non-Sjӧgren syndrome (Non-SS)) and 7 control subjects. The grade of squamous metaplasia was analyzed and the correlation between the grade and tear surface parameters was evaluated. Results: The squamous metaplasia grade score in CIC and CBC were 2.44±0.73 and 1.56±1.01 in SS patients (p=0.047), 1.53±0.74 and 0.80±0.78 in Non-SS patients (p=0.017), and 0.43±0.54 and 0.14±0.38 (p=0.250) in control subjects, respectively. In SS patients, the score correlated significantly with the symptom score, basal tear secretion, break-up time (BUT) and keratoepitheliopathy score in CBC (p＜0.05), but did not correlate with the tear surface parameters in CIC. In Non-SS patients, the score correlated significantly with the symptom score, basal tear secretion, BUT and keratoepitheliopathy score in CBC, and with the keratoepitheliopathy score in CIC (p＜0.05). Conclusions: CBC is a more useful method than CIC in the diagnosis of dry eye syndrome.

키워드

Conjunctival brush cytology, Conjunctival impression cytology, Dry eye syndrome, Tear surface parameter