녹내장안에서 단안 약물치료 시도의 효용성

• 영문명: The Usefulness of the Uniocular Drug Trial in the Glaucoma Eyes
• 발행기관: 대한안과학회
• 저자명: 신형호 유정권 최영재 김용연,Hyung Ho Shin, M.D., Chung Kwon Yoo, M.D., Young Jae Choi, M.D., Yong Yeon Kim, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume48,number1, 91~96쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.01.31

영문 초록

Purpose: This study was undertaken to evaluate if the reduction of intraocular pressure (IOP) observed in a uniocular trial correlates with an IOP reduction observed in the fellow eye. Methods: The study was performed on forty patients with bilateral glaucoma or suspect glaucoma who underwent a uniocular trial of 0.005% latanoprost and subsequently received the same drug in the fellow eye after 1 week. Inter-eye IOP variations were less than 3 mm Hg over two measurements, and were followed minimally for 4 weeks. The uniocular IOP reduction (IOP before medication - IOP after medication) and the net IOP reduction (IOP change in the trial eye after medication - IOP change in the fellow eye) were calculated. The uniocular IOP reduction and net IOP reduction in the trial eye was compared with the results from the fellow eye. Results: The mean uniocular IOP reduction in the trial eye and the fellow eye were 3.6±2.42 mm Hg and 2.78±2.16 mm Hg, respectively (r=0.390, r2=0.152, P=0.013). The mean net IOP reduction in the trial eye and the opposing eye were 3.55±1.70 mm Hg and 3.15±1.83 mm Hg, respectively (r=0.782, r2=0.612, P=0.000). Conclusions: A uniocular drug trial in patients with similar IOPs between their eyes can adequately predict the IOP lowering effect of a medication.

키워드

Net IOP reduction, Uniocular drug trial, Uniocular IOP reduction