엔지오제닌에 의한 가토 각막 혈관신생에 대한 라파마이신의 억제 효과

• 영문명: Inhibitory Effect of Rapamycin on Corneal Neovascularization induced by Angiogenin in Rabbits
• 발행기관: 대한안과학회
• 저자명: 권영삼 장수익 강동구 김재찬,Young Sam Kwon, Ph.D., Soo Ik Chang, Ph.D., Dong Ku Kang, M.S., Jae Chan Kim, Ph.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume46,number6, 1052~1059쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.06.30

영문 초록

Purpose: The purpose of this study was to determine whether immunosuppressant, rapamycin could inhibit corneal angiogenesis induced by angiogenin and to evalutate its role by micropocket assay. Methods: The rabbit`s eye was implanted intrastromally into the superior cornea with pellet for the control group, pellet containing of angiogenin for the angiogenin group, and pellet containing of angiogenin and rapamycin for the angiogenin+rapamycin group. Biomicrographically, corneal angiogenesis was evaluated for 14 days after pellet implantation, based on the number and the length of new vessels. The neovascularized cornea also was examined histologically. Results: We could observe that the angiogenin inducing corneal angiogenesis was inhibited by rapamycin. The score of neovascularization was significantly decreased in the angiogenin+rapamycin group than in the angiogenin group at 3, 7 and 10 days after pellet implantation (p<0.05). Histologically, the cornea of angiogenin+rapamycin group also showed much less new vessels than that of angiogenin group, in which inflammatory cells and edema was observed. Conclusions: Rapamycin appears to inhibit angiogenin induced angiogenesis in a rabbit corneal micropocket assay and may have therapeutic potential as an antiangiogenic agent.

키워드

Angiogenin, Neovascularization, Rapamycin