아벨리노각막이상증으로 진단된 한국인 환자의 각막병변의 분류 및 임상양상

• 영문명: The Classification and Clinical Characteristics in Korean Patients with Avellino Corneal Dystrophy
• 발행기관: 대한안과학회
• 저자명: 정소향 김창염 김응권,So-Hyang Chung, M.D., Chang-Yeom Kim, M.D., Eung-Kweon Kim, M.D., Ph.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume46,number6, 938~944쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.06.30

영문 초록

Purpose: To classify Avellino corneal dystrophy (ACD) into 3 groups by slit lamp photography and to evaluate the inter-group differences. Methods: DNA analysis was performed in one member from each of 45 families who were clinically diagnosed as ACD. Corneal opacities were classified into mild (group I), moderate (group II), and severe (group III) based on slit lamp photograph. Results: Six patients were confirmed as homozygous ACD and ninety-two as heterozygous ACD. One homozygous patient was revealed to have a novel phenotype. The age increased with increasing severity, and the proportion of females in group III was significantly higher than that of the other two groups (p=0.001). The prevalence of laser in situ keratomileusis (LASIK) increased in group III (p=0.001), and the incidence of pterygium increased in group I compared with the other two groups (p=0.025). Conclusions: ACD was aggravated with age, while pterygium and LASIK altered the natural course of ACD.

키워드

Avellino corneal dystrophy, Laser in situ keratomileusis, Pterygium, Slit lamp photography