토피라메이트에 의한 급성폐쇄각녹내장

• 영문명: Topiramate-induced Acute Angle-Closure Glaucoma
• 발행기관: 대한안과학회
• 저자명: 전찬 기창원,Chan Jeon, M.D., Chang-Won Kee, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume46,number11, 1944~1950쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.11.30

영문 초록

Purpose: We describe 2 cases of bilateral acute angle-closure glaucoma associated with topiramate, a drug that has recently been prescribed for epilepsy or weight reduction. Methods: A 51-year-old man and a 27-year-old woman, previously devoid of ocular problems, visited the emergency room with blurry vision after taking topiramate for epilepsy and weight reduction, respectively. Thorough medical history taking and ocular examinations including ultrasound biomicroscopy were performed. Results: Ultrasound biomicroscopy revealed supraciliary choroidal effusion causing forward displacement of the lens-iris diaphragm, which resulted in myopia, anterior chamber shallowing, and increased intraocular pressure by angle-closure. Discontinuation of topiramate and the administration of cycloplegics, steroids and pressure-lowering agents led to the resolution of the symptoms. Conclusions: An idiosyncratic reaction of topiramate may produce supraciliary choroidal effusion and ciliary body edema, resulting in anterior displacement of lens-iris diaphragm, increased myopia and acute angle-closure glaucoma. Thorough medical history taking and ocular examinations are necessary to rule out the drug-induced acute angle-closure glaucoma.

키워드

Angle-closure glaucoma, Choroidal effusion, Myopia, Topiramate