트리암시놀론이 배양된 사람 섬유아세포의 생존과 산화질소 생성에 미치는 영향

• 영문명: Effect of Triamcinolone Acetonide on the Survival and Nitric Oxide Production in Cultured Human Tenon`s Capsule Fibroblasts
• 발행기관: 대한안과학회
• 저자명: 이효원 김재우,Hyo-Won Lee, M.D., Jae-Woo Kim, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume46,number11, 1919~1924쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.11.30

영문 초록

Purpose: To investigate the effect of triamcinolone acetonide (TA) on cell survival and nitric oxide (NO) production in cultured human Tenon`s capsule fibroblast (FB) cells. Methods: After exposed to TA, indomethacin, and dexamethasone for 2 days, cell survival and nitrite production of primarily cultured human FB cells were assessed with MTT and Griess assays, respectively. Results: Cell survival increased after exposure to TA at low concentrations but decreased at high concentrations. TA decreased the production of NO significantly (p<0.05). Exposure to indomethacin and dexamethasone revealed similar results. Conclusions: Both the biphasic effect on cell survival and the decreased production of NO induced by TA in FB cells could affect conjunctival wound healing

키워드

Fibroblasts, Nitric oxide, Triamcinolone acetonide, Wound healing