공막 내 삽입한 생체분해성 고분자 매트릭스를 이용한 스테로이드 지속 방출 방법의 개발

• 영문명: The Development of Biodegradable Intrascleral Implant for Slow Releasing of Triamcinolone Acetonide
• 발행기관: 대한안과학회
• 저자명: 이준훈 임정훈 한영아 신재필 조경신 임정옥 김시열,Jun-Hun Lee, M.D., Jung-Hoon Lim, M.D., Young-A Han, Ph.D., Jae-Pil Shin, M.D., Kyung-Sin Cho, M.D., Jeong-Ok Lim, Ph.D., Si-Yeol Kim, M.D.
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume46,number11, 1894~1902쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2005.11.30

영문 초록

Purpose: In order to treat inflammatory and proliferative disorders of the posterior segment of the eye, the authors evaluated the use of a biodegradable intrascleral implant for slow release of triamcinolone acetonide (TA). Methods: The intrascleral implant (1 mm thick and 3 mm in diameter) was made of alginic acid and PLA (poly (D,L-lactide)) containing 4 mg of TA. In vitro release of TA was evaluated by HPLC. To evaluate in vivo release of TA, the implant was placed into a scleral pocket in 18 rabbit eyes and the concentrations of TA in the aqueous humor, vitreous, and retina-choroid-sclera were measured by HPLC at 1, 2, 4, 8, and 12 weeks after implantation. The toxicity and biocompatibility of the implant were evaluated by slit lamp examination, IOP, electroretinogram, and light microscopy. Results: In vitro study demonstrated that the implant released TA in controlled manner for at least 8 months. The TA detected in the vitreous after 8 to 12 weeks and was not detected in retina-choroid-sclera at 8 weeks after implantation. The TA was not detected in aqueous humor. No significant toxicity to the retina was observed. Conclusions: These results suggest that the intrascleral implant of TA could be a promising system for the delivery of steroids to the posterior segment of eye in cases of inflammatory or proliferative disorders of posterior segment.

키워드

Alginic acid, Intrascleral implant, PLA, Sustained drug delivery, Triamcinolone acetonide