에스트로젠 수용체알파에 의한 Hypoxia Inducible Factor-1의 전사 활성조절

• 영문명: Activation of Hypoxia Inducible Factor-1 Alpha by Estrogen Receptor Alpha
• 발행기관: 대한약학회
• 저자명: 유광희(KwangHee Ryu) 이영주(KwangHee Ryu)
• 간행물 정보: 『약학회지』제54권 제2호 (2010년), 102~105쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.04.30

영문 초록

Our previous results showed that hypoxia inducible factor-1 (HIF-1) activated estrogen receptor (ER) in the absence of ligand. In this study, we have studied the effect ER overexpression on the activation of HIF-1. ER overexpression induced transcription activation of hypoxia response element driven luciferase and vascular endothelial growth factor. As a negative control, the effect of ER on androgen receptor response element was used. Our result indicate that the two ERα and HIF-1 signaling pathways shares part of the activation pathway.

키워드

hypoxia ERα HIF-1 VEGF