1-Bromopropane의 간독성에 미치는 N-Acetyl Cysteine과 Silymarin의 영향

• 영문명: Effects of N-Acetyl Cysteine and Silymarin on 1-Bromopropane-induced Hepatotoxicity in Mice
• 발행기관: 대한약학회
• 저자명: 이상규(Sang Kyu Lee) 강미정(Mi Jeong Kang) 전태원(Tae Won Jeon) 정태천(Tae Cheon Jeong)
• 간행물 정보: 『약학회지』제54권 제2호 (2010년), 97~101쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.04.30

영문 초록

Recently, it was found that the formation of reactive metabolites by cytochrome P450s as well as the depletion of glutathione would play important roles in hepatotoxicity induced by 1-bromopropane. In the present study, possible roles of anti-oxidants in 1-bromopropane-induced hepatotoxicity were investigated in male ICR mice. The hepatotoxicity induced by 1-bromopropane was significantly protected by the co-treatment with either N-acetyl cysteine or silymarin. 1-Bromopropane-induced decrease in hepatic glutathione level was significantly protected by the pretreatment with N-acetyl cysteine. Taken together, the present results indicated that the reduction of hepatic glutathione level caused by 1-bromopropane treatment might be associated in 1-bromopropane-induced hepatotoxicity in mice.

키워드

1-bromopropane hepatotoxicity N-acetyl cysteine silymarin lipid peroxidation in vivo