BALB/c 및 NC/Cga 마우스의 아토피성 피부질환모델에서 생약조성물 SPZZC※의 치료효능

• 영문명: Effect of SPZZC, a Composition of Herb Extracts, on Atopic Drematitis in BALB/c and NC/Cga Mouse
• 발행기관: 대한약학회
• 저자명: 이금선(Geum Seon Lee) 아이크(Iik Dela Pena) 최지영(Ji Young Choi) 윤서영(Seo Young Yoon) 최종현(Jong Hyun Choi) 강태진(Tae Jin Kang) 오세군(Se Koon Oh) 정재훈(Jae Hoon Cheong)
• 간행물 정보: 『약학회지』제52권 제2호 (2008년), 232~239쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2008.04.30

영문 초록

The aim of this study was to evaluate if a composition of herb extracts, PLX-PLS was effective to treat atopic dermatitis (AD) in mice. SPZZC is a composition of herb extracts containing the roots of Scopolia parviflora and Paeonia lactiflora, the herb of Zizania caudiflora, the fruit of Ziziphus jujuba and the leaf of Chinese arborvitae. AD in BALB/c mouse was induced by patching ovoalbumin on the backside, while it in NC/Nga mouse was induced by repeated application of 1- chloro 2,4-dinitrobenzene (DNCB). Mice were topically treated with SPZZC or Domohorn ointment on the backside for 2 weeks (BALB/c) or 1 week (NC/Nga). Scratching behavior, clinical skin severity and the levels of WBC, neutrophil, eosinophil and total serum IgE were measured. After AD induction, scores of scratching behavior and clinical skin severity and the levels of WBC, neutrophil, eosinophil and total serum IgE were increased. Treatment with SPZZC significantly decreased scores of scratching behavior and clinical skin severity in a dose dependent manner in NC/Nga and BALB/c mice. Treatment with SPZZC 2% significantly decreased also the levels of WBC, neutrophil, eosinophil and total serum IgE. Especially, treatment of SPZZC 2% reduced more rapidly score of clinical skin severity than clobetasol cream. These results suggest that the SPZZC may be an alternative substance for the management of AD.

키워드

atopic dermatitis scratching behavior clinical skin severity WBC neutrophil eosinophil IgE