6-(티에닐메칠렌)페남 설폰의 합성과 B-Lactamase 저해활성

• 영문명: Synthesis of 6-(Thienylmethylene)penam Sulfones and their p-Lactamase Inhibitory Activities
• 발행기관: 대한약학회
• 저자명: 김동현(Dong Hyeon Kim) 프리텀다빠(Pritam Thapa) 라다깔끼(Radha Karki) 장영동(Yurngdong Jahng) 이응석(Eung-Seok Lee)
• 간행물 정보: 『약학회지』제51권 제6호 (2007년), 447~454쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.12.31

영문 초록

The resistance of bacteria against β-lactam antibiotics is mainly caused by the production of β-lactamase enzymes. β-Lactamase inhibitors are used in combination with known antibiotics to overcome the growing problem of bacterial resistance. We prepared 6-(thienylmethylene)penam sulfones for the development of potent β-lactamase inhibitors and evaluated their β-lactamase inhibitory activities.

키워드

β-lactamase inhibitor sulbactam bacterial resistance 6-(thienylmethylene)penam sulfone