낙엽송층버섯의 Notric Oxide 생성저해 물질

• 영문명: Inhibitors of Nitric Oxide Syntheasis from Phellinus pini in Murine Macrophages
• 발행기관: 대한약학회
• 저자명: 장현진(Hyun-Jin Jang) 김안근(Ahn-Keun Kim) 표명윤(Myoung-Yun Pyo) 양기숙(Ki-Sook Yang)
• 간행물 정보: 『약학회지』제51권 제6호 (2007년), 430~434쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.12.31

영문 초록

The anti-inflammatory activity of fruit body of Phellinus pini was investigated by activity-guided fractionation. From the screening of each fraction for the inhibitory activity of NO production in lipopolysaccaride (LPS) activated RAW 264.7 cells, methanol extract and its hexane soluble fraction of Phellinus pini exhibited inhibition of NO production compared with LPS control without toxicity. The hexane soluble fraction showed dose-dependent inhibition of NO production. The active hexane fraction was repeatedly chromatographed over silica gel, ergosta-7,24(28)-dien-3-ol(1) and ergosterol peroxide (2) were isolated and identified. Ergosterol derivatives were inhibited NOS activation, IC50 of them were 18.9±3.9 μM (1) and 20.4±4.5 uM (2).

키워드

Phellinus pini ergosta-7,24(28)-dien-3-ol ergosterol peroxide nitric oxide RAW 264.7 cell