GC/MS를 이용한 모발 중 메스암페타민 및 암페타민 분석의 측정불확도 평가

• 영문명: Uncertainty Evaluation of the Analysis of Methamphetamine and Amphetamine in Human Hair by GC/MS
• 발행기관: 대한약학회
• 저자명: 김진영(Jin Young Kim) 김종상(Jong Sang Kim) 김민경(Min Kyoung Kim) 이재일(Jae Il Lee) 서용준(Yong Jun Suh) 인문교(Moon Kyo In)
• 간행물 정보: 『약학회지』제51권 제3호 (2007년), 206~213쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.06.30

영문 초록

Recently estimating the uncertainty of an analytical result has become an essential part of quantitative analysis. This study describes the uncertainty of the measurement for the determination of methamphetamine and its major metabolite amphetamine in human hair. The method consists of washing, drying, weighing, incubation and extraction with methanolic HCl solution, clean-up, trifluoroacetyl derivatization, and qualification/quantification of residues by gas chromatography/mass spectrometry (GC/MS). Traceability of measurement was established through traceable standards and calibrated volumetric equipment and measuring instruments. Measurement uncertainty associated with each analyte in real samples was estimated using quality control (QC) data. The main source of combined standard uncertainty comprised two components, which are uncertainties associated with calibration linearity and variations in QC, while those associated with preparation of analytical standards and sample weighing were not so important considering the degree of contribution. Relative combined standard uncertainties associated with the described method ranged for individual analytes from 4.99 to 5.03%.

키워드

uncertainty of measurement methamphetamine amphetamine hair-analysis GC/MS