마우스 간염바이러스(MHV-2)에 의해 유발된 전격성 바이러스간염에 대한 비페닐메칠디카르복실레이트/아만타딘제제의 간보호 및 잠재적 항바이러스효과

• 영문명: Hepatoprotective and a Potential Antiviral Effect of Biphenyl Dimethyl Dicarboxylate/Amantadine for and Acute Viral Hepatitis Induced by MHV-2 in ICR Mice
• 발행기관: 대한약학회
• 저자명: 주성수(Seong Soo Joo) 진혁준(Hyouk Jun Chin) 원태준(Tae Joon Won) 장수길(Su Kil Jang) 황광우(Kwang Woo Hwang) 이도익(Do Ik Lee)
• 간행물 정보: 『약학회지』제51권 제3호 (2007년), 194~198쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2007.06.30

영문 초록

The mouse hepatitis virus (MHV-2) induces broad collapses, focal necrosis and cytolysis of hepatocytes, and leads to death after three to five days of intraperitoneal injection in mice. The present study investigated whether the combinatorial treatment of dimethyl dicarboxylate/amantadine (2:1) showed hepatoprotective and/or antiviral properties in MHV-2 infected ICR mice. In the study, we found that dimethyl dicarboxylate/amantadine group (VDDBA) increased the survival rate (30.8%) when compared to positive control, VL (7.7%) and that VDDBA lengthened the survival time (4.2d)after MHV-2 infection. In addition, ALT and AST were well regulated when treated with VDDBA (p<0.01). Finally, we concluded that those results were probably from the inhibition of viral replication and at least antiproliferative effect on MHV-2.

키워드

MHV-2 dimethyl dicarboxylate amantadine HBV ICR mouse lamivudine