3-[(4-카르복시-5-에틸티오이소티아졸-3-일)옥시메틸] 세파로스포린 유도체들의 합성 및 항균력에 관한 연구

• 영문명: A Study on the Synthesis and Antibacterial Activities of 3-[(4-Carboxy-5-ethylthioisothiazol-3-yl)oxymethyl] cephalosporin Derivatives
• 발행기관: 대한약학회
• 저자명: 최원식(Won Sik Choi) 박의석(Eui Suk Park) 박규종(Kyu Jong Park) 이영행(Young Haeng Lee)
• 간행물 정보: 『약학회지』제44권 제2호 (2000년), 155~161쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2000.04.29

영문 초록

New cephalosporin antibiotics, 3-[(4-carboxy-5-ethylthioisothiazol-3-yl)oxymethyll-7-[(1H-tetra-zol-1-yl)acetamido]-3-cephem-4-carboxylic acid 2, 3-[(4-carboxy-5-ethylthioisothiazol-3-yl)oxymethyl]-7-[(2-aminothiazol-4-yl)acetamidol-3-cephem-4-carboxylic acid 3, 3-[(4-carboxy-5-ethylthioisothiazol-3-yl)-oxymethyl]-7-[5-(ethylthio-3-hydroxyisothiazol-4-yl)carboxamido]-3-cephem-4-carboxylic acid 4, 3-[(4-carboxy-5-ethylthioisothiazol-3-yl)oxymethyl]-7-[(Z)-2-(fur-2-yl)-2-(methoxyimino)acetamido]-3-cephem-4-carboxylic acid 5, 7-[(Z)-2-(2-aminothiazol-4-yl)-2-[(alkoxyimino)acetamido]-3-[(4-carboxy-5-ethylthioisothiazol-3-yl)oxymethyl]-3-cephem-4-carboxylic acid 6-8 were synthesized. Antibacterial activities and structure-activity relationships of these new cephalosporin derivatives were examined. Among them, 7-[(Z)-2-(2-aminothiazol-4-yl)-2-(1-carboxy-l-methylethoxyimino)acetamido]-3-[(4-carboxy-5-ethylthylthioisothiazol-3-yl)oxymethyl]-3-cephem-4-carboxylic acid 7 exhibited good antibacterial activities compared to cefotaxime and ceftriaxone.

키워드

Cephalosporin 7-ACA aminothiazole MIC cefotaxime ceftriaxone.