인삼 단백분획물이 일차배양한 계배의 뇌세포 및 DRG에 미치는 영향

• 영문명: Effects of the Protein Fraction of Panax ginseng on Primary Cultured Chicken Brain Cells and DRG
• 발행기관: 대한약학회
• 저자명: 박미정(Mi Jung Park) 송진호(Jin Ho Song) 김선여(Sun Yeou Kim) 김영중(Young Choong Kim)
• 간행물 정보: 『약학회지』제34권 제5호 (1990년), 365~373쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.10.28

영문 초록

The effects of the protein fraction of Panax ginseng on primary cultured chicken embryonic brain cells and DRG cultured with a deficient medium were studied. The protein fraction was further fractionated into four groups according to the molecular weight; larger than 10,000 dalton(fraction A), between 5,000 and 10,000 daltons(fraction B), between 1,000 and 5,000 daltons(fraction C), between 500 and 1,000 daltons(fraction D). All four protein fractions at the concentration of 100mcg/ml significantly increased the number of the brain cells which promoted the neurite outgrowth. The activity of PDHC in the brain cells was elevated significantly by the protein fraction B at the concentration of 100mcg/ml. It was noted that 100mcg/ml protein fraction C and D significantly enhanced the synthesis of protein in the brain cells. At the concentration of 100mcg/ml, the protein fraction B enhanced RNA synthesis and the protein fraction. A significantly enhanced DNA synthesis in the brain cells. The protein fractions B, C, and D significantly promoted the neurite outgrowth of DRG at the concentration of 100mcg/ml.

키워드

Panax ginseng Protein fraction Primary culture Chicken embryonic brain cells DRG PDHC Protein synthesis RNA synthesis DNAsynthesis