일산화탄소 중독이 뇌내 아미노산 신경전달물질 함량변화에 미치는 영향

• 영문명: The Effect of Carbon Monoxide Intoxication on the Changes in Contents of Amino Acid Neurotransmitter of Rat Brain
• 발행기관: 대한약학회
• 저자명: 정민정(Min Jung Jung) 박송자(Son Ja Park) 이선희(Sun Hee Lee) 윤재순(Jae Soon Yun)
• 간행물 정보: 『약학회지』제34권 제5호 (1990년), 323~333쪽, 전체 11쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.10.28

영문 초록

To study influence of carbonmonoxide (CO) poisoning on the content of amino acid neurotransmitter in brain, male rat was exposed to CO 5000 ppm for 30 minutes (60-75% HbCO). Aspartic acid and glutamic acid level in the cerebral cortex and aspartic acid level in the striatum were significantly decreased. GABA level in the cerebral cortex was significantly increased after the 30 and 60 minutes of CO intoxication. Taurine level in both the cerebral cortex and the striatum was increased although nonsignificant. Consequently, the CO-induced hypoxia brain showed lower level of excitatory neurotransmitter, aspartic acid and glutamic acid and higher level of inhibitory nelirotransmitter, GABA and taurine. These results suggest that the change in content of amino acid neurotransmitter in the rat brain may be concerned with several CO poisoning symptoms.

키워드

Amino acid neurotransmitter aspartic acid glutamic acid taurine gamma-aminobutyric acid CO intoxication.