Protoberberine 유도체합성 및 활성연구

• 영문명: Synthesis of Protoberberine Derivatives and Studies on Their Biological Activities
• 발행기관: 대한약학회
• 저자명: 이마세(Ma Sae Lee) 정성현(Sung Hyun Chung) 김동현(Dong Hyun Kim) 정세영(Se Young Choung) 김신규(Sin Kyu Kim)
• 간행물 정보: 『약학회지』제34권 제5호 (1990년), 296~301쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.10.28

영문 초록

Irradiation of the berberinephenolbetaine in a stream of argon produced the 8,14-cycloberberines[1]. On treatment with ethylchloroformate C8-N bond cleavage of the compound[1] occurred, accompanied with dehydrochlorination to give 7-ethylcarboxyisoquinoline[3], and the product[3] treated with strong alkali solution to give the 13-oxonorotensane[4] in 64% yield. Irradiation of the compound[4] converted easily to dihydro-8H-dibenzo[a, g] quinolizine-8-one[5]. and then the compound[5] was treated with methyliodide to give the 8-oxo-quinolizinium methiode. The intermediate colume chromatography on IRA-400 afforded the benzo[c, g]azecine-5-one[6] in 63% yield. The result of biological activities for these compounds are also presented.

키워드

protoberberine derivatives biological activities