충치균에 대한 생리활성 생약성분의 분리 및 약효평가(2) 호장근의 항균성분과 안정성에 대하여

• 영문명: The Isolation and Evaluation of Bioactive Components from Crude Drugs Against a Cariogenic Bacterium, Streptococcus mutans OMZ 176(2) An Antibacterial Component of Polygoni Radix and Its Safety
• 발행기관: 대한약학회
• 저자명: 배기환(Ki Hwan Bae) 김봉희(Bong Hee Kim) 명평근(Pyung Keun Myung) 정경수(Kyeong Soo Chung) 백정화(Jung Hwa Baek)
• 간행물 정보: 『약학회지』제34권 제4호 (1990년), 277~281쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.08.28

영문 초록

The isolation and identification of an antibacterial component, from Polygoni Radix against a cariogenic bacterium Streptococcus mutans OMZ 176, were carried out for development of anticariogenic agents. The bioactive component was identified to be emodin. The minimal inhibitory concentration (MIC) of emodin was 100mcg/ml against S. mutans OMZ 176. The bioactive component emodin weakly inhibited beta-lactamase activity with the inhibition ratio of 1.7, 4.3 and 7.6% at the concentration of 50, 100, and 200mcM, respectively. Emodin exhibited slight phototoxicity when analysed by the photohemolysis method.

키워드

Emodin Polygoni radix Streptococcus mutans OMZ 176 β-lactamase activity photohemolysis