Acetylshikonine 및 합성 Naphthazarin 유도체의 L1210 및 S-180 암에 대한 항암효과

• 영문명: Antitumor Effects of Acetylshikonine and some Synthesized Naphthazarins on L1210 and S-180 Systems
• 발행기관: 대한약학회
• 저자명: 김현(Hyun Kim) 안병준(Byung Zun Ahn)
• 간행물 정보: 『약학회지』제34권 제4호 (1990년), 262~266쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.08.28

영문 초록

Acetylshikonine, isolated from the root of Lithospermitm erythrorhizon showed a strong cytotoxic activity (ED50=0.10mcg/ml against L1210 cell and T/C = 182% in ICR mice bearing S-180 at a dose of 5mg/kg. Administrations of 10mg/kg and 15mg/kg reduced the T/C values to 60 and 77% respectively. Higher doses reveal toxicity. Seven naphthazarin derivatives synthesized showed good cytotoxic activities against L1210 cell. Especially, naphthazarin and hydronaphthazarin have strong activities (ED50=0.05mcg/ml for both). Naphthazarin showed a severe toxic effect on ICR mice bearing S-180: no significant toxic effect was observed at a dose of 1mg/kg or 2mg/kg, but a severe toxicity (T/C = 23%) by administration of 5mg/kg. Alkylation of C-2 of naphthazarin is necessary for reducing the toxic effect on ICR mice bearing S-180.

키워드

Acetylshikonine some synthesized naphthazarins L1210 S-180 systems lithospermum erythrorhizon antitumor effect.