Arachidonic Acid의 개 신장기능에 미치는 영향

• 영문명: Effect of Arachidonic Acid on Renal Function of Dog.
• 발행기관: 대한약학회
• 저자명: 고석태(Suk Tai Ko) 박화숙(Hwa Sook Park)
• 간행물 정보: 『약학회지』제34권 제4호 (1990년), 252~261쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.08.28

영문 초록

Arachidonic acid which is precursor of prostaglandins, when administered(100.0mcg/kg, or 100.0mcg/kg/min) intravenously, did not influence on renal function of dog. Arachidonic acid, when infused (10.0mcg/kg/min) into a renal artery, produced marked diuretic action accompanied with augmentation of renal plasma flow and with little changed glomerular filtration rate, and exhibited the increased clearances of osmolar substance and free water, and the decreased reabsorption rates of sodium and potassium in renal tubules in only experimental kidney, but did not influenced at all in control kindey. The diuretic action of arachidonic acid infused into a renal artery was not affected by pretreatment of indomethacin (10.0 mg/kg. i.v) which is inhibitor of cyclooxygenase. Above results suggest that arachidonic acid infused into a renal artery produced diuretic action through direct renal hemodynamic changes, that is mediated by reduction of postglomerular resistance being caused by dilation of vas efferense.

키워드

chidonic acid dog kidney diuretic action renal hemodynamic changes indomethacin.