가토에서의 Praziquantel의 체내 동태

• 영문명: Pharmacokinetics of Praziquantel in Rabbits
• 발행기관: 대한약학회
• 저자명: 이미정(Mi Jeong Lee) 심창구(Chang Koo Shim) 이민화(Min Hwa Lee) 김신근(Shin Keun Kim)
• 간행물 정보: 『약학회지』제34권 제1호 (1990년), 40~46쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1990.02.28

영문 초록

Pharmacokinetic studies on praziquantel in rabbits were performed in this paper. The pharmacologically active parent drug was separated from the pharmacologically inactive metabolites by HPLC method. The pharmacokinetic parameters of parent drug were obtained. In vitro partition to blood cells of praziquantel was measured. The mean value (n = 3) of partition to blood cells was 44% at concentrations between 1mcg/ml and 40mcg/ml. Therefore, the relatively high partition to blood cells should be considered in further pharmacokinetic studies on praziquantel.

키워드

Praziquantel Pharmacokinetics