Angiotensin II의 이뇨작용

• 영문명: Diuretic Action of Angiotensin II in Dog
• 발행기관: 대한약학회
• 저자명: 고석태(Suk Tai Ko) 이민재(Min Jae Lee) 허영근(Young Keun Hur)
• 간행물 정보: 『약학회지』제33권 제3호 (1989년), 183~190쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.06.25

영문 초록

Angiotensin II, adminstered (infused or injected) intravenously, elicited the antidiuretic action with the decreased parameters of renal function at a small dose (0.0lmcg/kg/min), whereas, at a large dose (0.03, 0.1mcg/kg/min and 5.0mcg/kg), it produced the diuretic action accompanied the increased amounts of sodium and potassium excreted in urine (ENa and RK). At this time, glomerular filtration rates (GFR) were weakened slightly and renal plasma flows (RPF) were reduced markedly, and then filtration fractions (FF) were increased. Angiotensin II, infused into a renal artery, exhibited antidiuretic action at a small dose (0.003mcg/kg/min), and diuretic action at a large dose (0.0lmcg/kg/min), only in infused (experimental) kidney. The mechanism of the action was similar to the cases of the intravenous angiotensin II. The above results suggest that angiotensin II of a large dose produced diuretic action due to mechanism inhibiting reabsorption of electrolytes in renal tubules, mainly in proximal tubule in dog.

키워드

Angiotensin II glomerular filtration rates renal plasma flows filtration fractions renal artery kidney diuretic action dog