Pectin-Gelatin Complex Coacervation 에 의한 Indomethacin의 Microencapsulation 에 관한 연구

• 영문명: Microencapsulation of Indomethacin by Pectin-Gelatin Complex Coacervation Method
• 발행기관: 대한약학회
• 저자명: 구영순(Young Soon Ku) 진수영(Soo Young Chin)
• 간행물 정보: 『약학회지』제33권 제3호 (1989년), 191~202쪽, 전체 12쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1989.06.25

영문 초록

Indomethacin, a non-steroidal antiinflammatory drug inducing gastric irritation, was microencapsulated using pectin-gelatin complex coacervation method. Optimum conditions for microencapsulation and dissolution characteristics of the microcapsules were studied. The optimum pH and pectin-gelatin ratio for microencapsulation were 3.8 and 1:2 respectively. As concentration of colloid solution increased, wall thickness of microcapsules were increased. The dissolution rate of Indomethacin-pectin-gelatin microcapsules prepared by 1.5% and 2% colloid solution were similar but slower than that of Indomethacin-pectin-gelatin microcapsules prepared by 1% colloid solution. The 50% release time (T50%)of Indomethacin-pectin-gelatin microcapsules prepared by 1%, 1.5% and 2% colloid solutions were 3 min, 5 min, and 6 min respectively while that of Indomethacin powder was 50 min.

키워드

Complex coacervation Indomethacin microencapsulation