Mercuric chloride 유발 신부전에서 산소유리기에 미치는 Sodium selenite의 영향

• 영문명: Influence of sodium selenite on oxygen free radical in mercuric chloride induced renal failure
• 발행기관: 대한약학회
• 저자명: 김형춘(Hyoung Chun Kim) 주왕기(Wang Kee Jhoo) 허인회(In Hoi Huh)
• 간행물 정보: 『약학회지』제32권 제4호 (1988년), 287~293쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.08.29

영문 초록

Oxygen free radical have recently been found to mediate cell injury after ischemia in the kidney. The purpose of our study was to determine whether selenium had an effect on damage mediated by oxygen free radical in inorganic mercury induced renal failure, toxic model of renal failure. Toxic renal failure model was produced by subcutaneous injection of mercuric chloride (4mg/kg) once a day for 7 consecutive days. In additionally, coadministration of sodium selenite (1mg/kg) was performed by the same condition. As a consequence of this study, we were able to detect partially unequivocal role of selenium as below dipicted. The combination of sodium selenite showed that markedly inhibited production of superoxide radical in mercuric chloride alone. On the other hand, combined sodium selenite was unable to enhance against significantly lowered superoxide dismutase activity after mercuric chloride insult. However, simultaneous administration of sodium selenite was inclined to induce mitochondrial superoxide dismutase and catalase.