HPLC법에 의한 종합감기약중 구성성분의 동시 정량

• 영문명: HPLC Study on the Determination of Active Ingredients in Cough-Cold Preparations.
• 발행기관: 대한약학회
• 저자명: 이창현(Chang Hyun Lee) 이계주(Gye Ju Rhee)
• 간행물 정보: 『약학회지』제32권 제4호 (1988년), 251~257쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.08.29

영문 초록

A simple and sensitive HPLC method was developed for the simultaneous determination of ten kinds of active ingredients formulated in commercial cough-cold mixtures. A group of Pseudoephedrine.HCl, dl-Methylephedrine.HCl, Noscapine, Chlorophenylamine maleate, Dextromethorphan.HBr and Phenylpropanolamine.HCl were determined at 254nm using a Novapak C18 column with mobile phase consisting of a mixture of methanol-acetonitrile-1,4-dioxane-tetrahydrofuran-water(12:20:20:5:43, pH4.7) containing 0.013M-dioctyl sodium sulfosuccinate. The another group of Acetoaminophen, Caffeine, Guaifenesin and Ethenzamide were also determined at 254nm using a Novapak C18 column as the stationary phase, and a mixture of methanol-1% aqueous acetic acid (3:7). The results indicate that these methods are accurate and precise with relative standard deviation of not more than 1% (n=5) for the above active ingredients.