프로리포솜의 제조 및 평가

• 영문명: Preparation and Evaluation of Proliposome
• 발행기관: 대한약학회
• 저자명: 정대식(Dae Sik Chung) 심창구(Chang Koo Shim) 이민화(Min Hwa Lee) 김신근(Shin Keun Kim)
• 간행물 정보: 『약학회지』제32권 제4호 (1988년), 234~238쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1988.08.29

영문 초록

Proliposome of Sudan IV was prepared according to Payne et al. and evaluated for it''s size distribution, surface characteristics and conversion to liposome in aqueous medium. The manufacturing procedures for proliposomes involve the coating of phospholipid solution with Sudan IV on the surface of sorbitol particle in rotary vacuum evaporator. As a result, dry, free flowing and stable proliposome was obtained and multi-lamellar liposome of Sudan IV was formed spontaneously when water were added to this. Proliposomes were expected as a probable answer for the physical instability of conventional liposomes.