Picric acid를 전자수용체로 한 Phenothiazine계 화합물의 정량법

• 영문명: Spectrophotometric Determination of Phenothiazine Derivatives by using Picric acid as Electron Acceptor
• 발행기관: 대한약학회
• 저자명: 옥치완(Chi Wan Ock) 신태용(Tae Yong Shin)
• 간행물 정보: 『약학회지』제31권 제5호 (1987년), 322~329쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1987.10.30

영문 초록

A rapid and sensitive spectrophotometric method has been developed for quantitation of some phenothiazine derivatives (PTZDS). The method depends on the formation of insoluble yellow complexes between PTZDS and picric acid (PCA) in aqueous layer. These complexes are quantitatively extracted from aqueous phase into chloroform. The binding ratio of PTZDS-PCA complexes were presumed as PTZDS-1 to PCA-1 by means of mole ratio and continuous variation methods. The complexes are stable for more than 24 hours in chloroform layer at room temperature. Most of compounds associated with pharmaceutical preparation of PTZDS do not interfere with this method. However, chlorpheniramine and diphenhydramine interfere with the method. The binding state of PTZDS-PCA complexes were presumed by IR and 1H-NMR spectra as intermolecular hydrogen bonding.