Capsaicinoids의 미생물전환 메카니즘 진균에 의한 Capsaicinoids의 일반적 분해대사형태

• 영문명: Microbial Transformation Mechanism of Capsaicinoids General Biodegradation Pattern of Capsaicinoids by Fungi
• 발행기관: 대한약학회
• 저자명: 이익수(Ik Soo Lee) 이상섭(Sang Sup Lee)
• 간행물 정보: 『약학회지』제31권 제5호 (1987년), 280~285쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1987.10.30

영문 초록

There are three plausible bioconversion pathways in biodegradation mechanism of capsaicinoids; first, side chain degradation through omega-hydroxylation and beta-oxidation, secondly, aromatic ring hydroxylation, and lastly, hydrolysis on the acidamide linkage. In microbes, it was reported that capsaicin and its synthetic analog, nonoylvanillylamide(NVA), could be metabolized to N-vanillylcarbamoylbutyric acid via omega-hydroxylation and consecutive beta-oxidations by Aspergillus niger. In order to broaden the scope of microbial degradation of capsaicinoids, over thirty strains of various fungi including Aspergillus, Penicillum, Mycotypha, Gliocladium, Paecilomyces, Byssoclamys, Conidiobolus, Thamnidium, and Entomophthora. It was observed that almost all the strains examined oxidized the side chain of capsaicids as A. niger did. These observations strongly support the notion that side chain degradation is the most dominant pathway in the microbial degradation of capsaicinoids.