1,3-Oxazine화합물로부터 4-Hydroxy-2-Methyl-N-(Cyclohexyl)-2H-1,2-Benzothiazine-3-Carboxamide-1,1-Dioxide의 합성

• 영문명: Synthesis of 4-Hydroxy-2-Methyl-N-(Cyclohexyl)-2H-1,2-Benzothiazine-3-Carboxamide-1,1-Dioxide via 1,3-Oxazine Compounds
• 발행기관: 대한약학회
• 저자명: 서정진(Jung Jin Suh) 홍유화(You Hwa Hong)
• 간행물 정보: 『약학회지』제31권 제4호 (1987년), 219~223쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1987.08.30

영문 초록

2-Cyclohexylimino-3-cyclohexyl-5-methyl-4-oxo-2H,5H-1,3-oxazino[5,6-C]-1,2- benzothiazine-6,6-dioxide 2 was hydrolized in d-HCl/CH3CN to give 5-methyl-3-cyclohexyl-2H,5H-1,3-oxazino[5,6-C]-1,2 benzothiazine-2,4(3H)-dione 6,6-dioxide 3 in 82% yield. The alkaline hydrolysis of 3 afforded to 4-hydroxy-2-methyl-N-(cyclohexyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide 4 in 88% yield. On the other hand 3 was synthesized from 4 and ethylchloroformate on the reversed procedure.