항결핵약물의 상호작용 (II) 리팜피신과 이소니아짓의 약물상호작용

• 영문명: Interaction of Antitubercular Drug (II) Drug Interaction of Rifampicin and Isoniazid
• 발행기관: 대한약학회
• 저자명: 범진필(Jin Pil Burm) 최준식(Jun Shik Choi) 이진환(Jin Hwan Lee)
• 간행물 정보: 『약학회지』제31권 제4호 (1987년), 204~212쪽, 전체 9쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1987.08.30

영문 초록

Rifampicin is an indispensable drug along with isoniazid for the control of tuberculosis and is usually prescribed as the combination of rifampicin and isoniazid. This paper is attemped to investigate the interaction of rifampicin and isoniazid. Isoniazid was administered orally at a dose of 30mg/kg of rabbits pretreated with rifampicin 7.5mg/kg, 15mg/kg, and 30mg/kg, respectively twice daily for 9 days. The results are as follows: The blood level and relative bioavailability of isoniazid were decreased significantly (p<0.05) by rifampicin at a dose of 15mg/kg and 30mg/kg. The renal clearance of total isoniazid and ratio of its metabolites to isoniazid were increased significantly (p<0.05) by rifampicin at a dose of 15mg/kg and 30mg/kg. It seemed to be due to enzyme induction by rifampicin. Elimination rate constant (beta) of isoniazid was increased and half life (t1/2beta) was decreased by rifampicin pretreatment. Dosaae regimen of isoniazid after long term administration of rifampicin should be adjusted carefully.