ICR 생쥐에서 엉겅퀴 잎 추출물의 항우울 효과

• 영문명: The Antidepressant Effects of Cirsium japomicum in ICR Mice
• 발행기관: 대한약학회
• 저자명: 박형근(Hyung Keun Park) 윤서영(Seo Young Yoon) 최종현(Jong Hyun Choi) 고홍숙(Hong Sook Ko) 서연원(Yeon Won Suh) 이용수(Yong Soo Lee) 김건희(Gun-Hee Kim) 정미숙(Mi Sook Chung) 정재훈(Jae Hoon Cheong)
• 간행물 정보: 『약학회지』제50권 제6호 (2006년), 429~435쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2006.12.31

영문 초록

The antidepressant effects of Cirsium japonicum compositae was investigated using open field test and forced swimming test. Total extract of Cirsium japonicum (CJ) was orally administered at dose of 20, 100, 300, 500mg/kg body weight. Supplementation of CJ increase dose-dependently movement, rearing frequency and total turn angle in the center area of open field in mice. Treatment of Cirsium japonicum's extract (360mg/kg, CJ) decreased immobile duration and increased mobile and strong mobile duration significantly, and it is comparable to that of imipramine and fluoxetine. These results indicate that CJ has antidepressant effect. Treatment of CJ did not induced any impairment in motor coordination and myorelaxation. These results indicate that the constituents or its complex of Cirsium japonicum could be a candidate of new antidepressant drug.

키워드

Cirsium japonicum antidepressants forced swimming test